By Pablo Steinberg
Explores the advantages and obstacles of the newest high-throughput screening methods
With its specialist insurance of high-throughput in vitro screening tools for toxicity trying out, this e-book allows researchers to speed up and streamline the evaluate and probability overview of chemical compounds and medication for toxicity. furthermore, it allows them to conform with the most recent criteria set forth by way of the U.S. nationwide study Council's "Toxicity trying out within the twenty first Century: A imaginative and prescient and method" and the E.U.'s succeed in laws. Readers will find a number of state-of-the-science, high-throughput screening tools offered through a gaggle of best experts in toxicology and toxicity testing.
High-Throughput Screening tools in Toxicity Testing is split into 5 parts:
- General features, together with predicting the toxicity capability of chemical compounds and medicine through high-throughput bioactivity profiling
- Assessing diversified cytotoxicity endpoints
- Assessing DNA harm and carcinogenesis
- Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity
- Assessing drug metabolism and receptor-related toxicity
Each bankruptcy describes technique ideas and comprises distinct information regarding information new release, info research, and functions in danger evaluation. The authors not just enumerate the benefits of each one high-throughput strategy over related traditional equipment, but in addition indicate the high-throughput method's boundaries and capability pitfalls. furthermore, the authors describe present study efforts to make high-throughput toxicity screening much more cost-efficient and streamlined.
Throughout the ebook, readers will locate lots of figures and illustrations to aid them comprehend and practice the newest high-throughput toxicity screening methods.
This booklet is perfect for toxicologists and different researchers who have to enforce high-throughput screening tools for toxicity trying out of their laboratories in addition to for researchers who have to evaluation the knowledge generated by means of those methods.